CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals
Identifieur interne : 002278 ( Main/Exploration ); précédent : 002277; suivant : 002279CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals
Auteurs : John Zaunders [Australie] ; Mark Danta [Australie] ; Michelle Bailey [Australie] ; Gerald Mak [Australie] ; Katherine Marks [Australie] ; Nabila Seddiki [France] ; Yin Xu [Australie] ; David J. Templeton [Australie] ; David A. Cooper [Australie] ; Mark A. Boyd [Australie] ; Anthony D. Kelleher [Australie] ; Kersten K. Koelsch [Australie]Source :
- Frontiers in Immunology [ 1664-3224 ] ; 2016.
Abstract
Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation, and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4+ T cells in gut-associated lymphoid tissue (GALT), but its impact on humoral immunity within GALT is unclear. Therefore, we studied CD4+ subsets, including T follicular helper cells (Tfh), as well as resident B cells that have switched to IgA production, in gut biopsies, from HIV+ subjects on suppressive ART compared to HIV-negative controls (HNC).
Twenty-three HIV+ subjects on ART and 22 HNC undergoing colonoscopy were recruited to the study. Single-cell suspensions were prepared from biopsies from left colon (LC), right colon (RC), and terminal ileum (TI). T and B lymphocyte subsets, as well as EpCAM+ epithelial cells, were accurately enumerated by flow cytometry, using counting beads.
No significant differences in the number of recovered epithelial cells were observed between the two subject groups. However, the median TI CD4+ T cell count/106 epithelial cells was 2.4-fold lower in HIV+ subjects versus HNC (19,679 versus 47,504 cells;
While there were lower absolute CD4+ counts in the TI and LC in HIV+ subjects on ART, they were not associated with significantly reduced Tfh cell counts or IgA+ B cells, suggesting that this important vanguard of adaptive immune defense against luminal microbial products is normalized following ART.
Url:
DOI: 10.3389/fimmu.2016.00438
PubMed: 27822211
PubMed Central: 5075890
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002493
- to stream Pmc, to step Curation: 002343
- to stream Pmc, to step Checkpoint: 000A92
- to stream PubMed, to step Corpus: 001707
- to stream PubMed, to step Curation: 001684
- to stream PubMed, to step Checkpoint: 001684
- to stream Ncbi, to step Merge: 003E37
- to stream Ncbi, to step Curation: 003E37
- to stream Ncbi, to step Checkpoint: 003E37
- to stream Main, to step Merge: 002277
- to stream Main, to step Curation: 002278
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CD4<sup>+</sup> T Follicular Helper and IgA<sup>+</sup> B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals</title><author><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Danta, Mark" sort="Danta, Mark" uniqKey="Danta M" first="Mark" last="Danta">Mark Danta</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>St Vincent’s Hospital, Clinical School</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mak, Gerald" sort="Mak, Gerald" uniqKey="Mak G" first="Gerald" last="Mak">Gerald Mak</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>St Vincent’s Hospital, Clinical School</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marks, Katherine" sort="Marks, Katherine" uniqKey="Marks K" first="Katherine" last="Marks">Katherine Marks</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Equipe 16, INSERM U955</institution>,<addr-line>Créteil</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Faculté de médecine, Université Paris Est</institution>,<addr-line>Créteil</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Vaccine Research Institute (VRI)</institution>,<addr-line>Créteil</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yin" sort="Xu, Yin" uniqKey="Xu Y" first="Yin" last="Xu">Yin Xu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Templeton, David J" sort="Templeton, David J" uniqKey="Templeton D" first="David J." last="Templeton">David J. Templeton</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>RPA Sexual Health, Royal Prince Alfred Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boyd, Mark A" sort="Boyd, Mark A" uniqKey="Boyd M" first="Mark A." last="Boyd">Mark A. Boyd</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Koelsch, Kersten K" sort="Koelsch, Kersten K" uniqKey="Koelsch K" first="Kersten K." last="Koelsch">Kersten K. Koelsch</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27822211</idno><idno type="pmc">5075890</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075890</idno><idno type="RBID">PMC:5075890</idno><idno type="doi">10.3389/fimmu.2016.00438</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">002493</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002493</idno><idno type="wicri:Area/Pmc/Curation">002343</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002343</idno><idno type="wicri:Area/Pmc/Checkpoint">000A92</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A92</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001707</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001707</idno><idno type="wicri:Area/PubMed/Curation">001684</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001684</idno><idno type="wicri:Area/PubMed/Checkpoint">001684</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001684</idno><idno type="wicri:Area/Ncbi/Merge">003E37</idno><idno type="wicri:Area/Ncbi/Curation">003E37</idno><idno type="wicri:Area/Ncbi/Checkpoint">003E37</idno><idno type="wicri:Area/Main/Merge">002277</idno><idno type="wicri:Area/Main/Curation">002278</idno><idno type="wicri:Area/Main/Exploration">002278</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">CD4<sup>+</sup> T Follicular Helper and IgA<sup>+</sup> B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals</title><author><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Danta, Mark" sort="Danta, Mark" uniqKey="Danta M" first="Mark" last="Danta">Mark Danta</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>St Vincent’s Hospital, Clinical School</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mak, Gerald" sort="Mak, Gerald" uniqKey="Mak G" first="Gerald" last="Mak">Gerald Mak</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>St Vincent’s Hospital, Clinical School</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Marks, Katherine" sort="Marks, Katherine" uniqKey="Marks K" first="Katherine" last="Marks">Katherine Marks</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Equipe 16, INSERM U955</institution>,<addr-line>Créteil</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Faculté de médecine, Université Paris Est</institution>,<addr-line>Créteil</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Vaccine Research Institute (VRI)</institution>,<addr-line>Créteil</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Yin" sort="Xu, Yin" uniqKey="Xu Y" first="Yin" last="Xu">Yin Xu</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Templeton, David J" sort="Templeton, David J" uniqKey="Templeton D" first="David J." last="Templeton">David J. Templeton</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>RPA Sexual Health, Royal Prince Alfred Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boyd, Mark A" sort="Boyd, Mark A" uniqKey="Boyd M" first="Mark A." last="Boyd">Mark A. Boyd</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>St Vincent’s Centre for Applied Medical Research, St Vincent’s Hospital</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Koelsch, Kersten K" sort="Koelsch, Kersten K" uniqKey="Koelsch K" first="Kersten K." last="Koelsch">Kersten K. Koelsch</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>The Kirby Institute, The University of New South Wales</institution>,<addr-line>Sydney, NSW</addr-line>,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Immunology</title><idno type="eISSN">1664-3224</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="ST1"><title>Background</title><p>Disruption of gastrointestinal tract epithelial and immune barriers contribute to microbial translocation, systemic inflammation, and progression of HIV-1 infection. Antiretroviral therapy (ART) may lead to reconstitution of CD4<sup>+</sup> T cells in gut-associated lymphoid tissue (GALT), but its impact on humoral immunity within GALT is unclear. Therefore, we studied CD4<sup>+</sup> subsets, including T follicular helper cells (Tfh), as well as resident B cells that have switched to IgA production, in gut biopsies, from HIV<sup>+</sup> subjects on suppressive ART compared to HIV-negative controls (HNC).</p></sec><sec id="ST2"><title>Methods</title><p>Twenty-three HIV<sup>+</sup> subjects on ART and 22 HNC undergoing colonoscopy were recruited to the study. Single-cell suspensions were prepared from biopsies from left colon (LC), right colon (RC), and terminal ileum (TI). T and B lymphocyte subsets, as well as EpCAM<sup>+</sup> epithelial cells, were accurately enumerated by flow cytometry, using counting beads.</p></sec><sec id="ST3"><title>Results</title><p>No significant differences in the number of recovered epithelial cells were observed between the two subject groups. However, the median TI CD4<sup>+</sup> T cell count/10<sup>6</sup> epithelial cells was 2.4-fold lower in HIV<sup>+</sup> subjects versus HNC (19,679 versus 47,504 cells; <italic>p</italic> = 0.02). Similarly, median LC CD4<sup>+</sup> T cell counts were reduced in HIV<sup>+</sup> subjects (8,358 versus 18,577; <italic>p</italic> = 0.03) but were not reduced in RC. Importantly, we found no significant differences in Tfh or IgA<sup>+</sup> B cell counts at either site between HIV<sup>+</sup> subjects and HNC. Further analysis showed no difference in CD4<sup>+</sup>, Tfh, or IgA<sup>+</sup> B cell counts between subjects who commenced ART in primary compared to chronic HIV-1 infection. Despite the decrease in total CD4 T cells, we could not identify a selective decrease of other key subsets of CD4<sup>+</sup> T cells, including CCR5<sup>+</sup> cells, CD127<sup>+</sup> long-term memory cells, CD103<sup>+</sup> tissue-resident cells, or CD161<sup>+</sup> cells (surrogate marker for Th17), but there was a slight increase in the proportion of T regulatory cells.</p></sec><sec id="ST4"><title>Conclusion</title><p>While there were lower absolute CD4<sup>+</sup> counts in the TI and LC in HIV<sup>+</sup> subjects on ART, they were not associated with significantly reduced Tfh cell counts or IgA<sup>+</sup> B cells, suggesting that this important vanguard of adaptive immune defense against luminal microbial products is normalized following ART.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Douek, D" uniqKey="Douek D">D Douek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenchley, Jm" uniqKey="Brenchley J">JM Brenchley</name></author><author><name sortKey="Douek, Dc" uniqKey="Douek D">DC Douek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guadalupe, M" uniqKey="Guadalupe M">M Guadalupe</name></author><author><name sortKey="Reay, E" uniqKey="Reay E">E Reay</name></author><author><name sortKey="Sankaran, S" uniqKey="Sankaran S">S Sankaran</name></author><author><name sortKey="Prindiville, T" uniqKey="Prindiville T">T Prindiville</name></author><author><name sortKey="Flamm, J" uniqKey="Flamm J">J Flamm</name></author><author><name sortKey="Mcneil, A" uniqKey="Mcneil A">A Mcneil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenchley, Jm" uniqKey="Brenchley J">JM Brenchley</name></author><author><name sortKey="Schacker, Tw" uniqKey="Schacker T">TW Schacker</name></author><author><name sortKey="Ruff, Le" uniqKey="Ruff L">LE Ruff</name></author><author><name sortKey="Price, Da" uniqKey="Price D">DA Price</name></author><author><name sortKey="Taylor, Jh" uniqKey="Taylor J">JH Taylor</name></author><author><name sortKey="Beilman, Gj" uniqKey="Beilman G">GJ Beilman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehandru, S" uniqKey="Mehandru S">S Mehandru</name></author><author><name sortKey="Poles, Ma" uniqKey="Poles M">MA Poles</name></author><author><name sortKey="Tenner Racz, K" uniqKey="Tenner Racz K">K Tenner-Racz</name></author><author><name sortKey="Horowitz, A" uniqKey="Horowitz A">A Horowitz</name></author><author><name sortKey="Hurley, A" uniqKey="Hurley A">A Hurley</name></author><author><name sortKey="Hogan, C" uniqKey="Hogan C">C Hogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenchley, Jm" uniqKey="Brenchley J">JM Brenchley</name></author><author><name sortKey="Price, Da" uniqKey="Price D">DA Price</name></author><author><name sortKey="Douek, Dc" uniqKey="Douek D">DC Douek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehandru, S" uniqKey="Mehandru S">S Mehandru</name></author><author><name sortKey="Dandekar, S" uniqKey="Dandekar S">S Dandekar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Douek, Dc" uniqKey="Douek D">DC Douek</name></author><author><name sortKey="Roederer, M" uniqKey="Roederer M">M Roederer</name></author><author><name sortKey="Koup, Ra" uniqKey="Koup R">RA Koup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenchley, Jm" uniqKey="Brenchley J">JM Brenchley</name></author><author><name sortKey="Price, Da" uniqKey="Price D">DA Price</name></author><author><name sortKey="Schacker, Tw" uniqKey="Schacker T">TW Schacker</name></author><author><name sortKey="Asher, Te" uniqKey="Asher T">TE Asher</name></author><author><name sortKey="Silvestri, G" uniqKey="Silvestri G">G Silvestri</name></author><author><name sortKey="Rao, S" uniqKey="Rao S">S Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burgener, A" uniqKey="Burgener A">A Burgener</name></author><author><name sortKey="Mcgowan, I" uniqKey="Mcgowan I">I Mcgowan</name></author><author><name sortKey="Klatt, Nr" uniqKey="Klatt N">NR Klatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guadalupe, M" uniqKey="Guadalupe M">M Guadalupe</name></author><author><name sortKey="Sankaran, S" uniqKey="Sankaran S">S Sankaran</name></author><author><name sortKey="George, Md" uniqKey="George M">MD George</name></author><author><name sortKey="Reay, E" uniqKey="Reay E">E Reay</name></author><author><name sortKey="Verhoeven, D" uniqKey="Verhoeven D">D Verhoeven</name></author><author><name sortKey="Shacklett, Bl" uniqKey="Shacklett B">BL Shacklett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehandru, S" uniqKey="Mehandru S">S Mehandru</name></author><author><name sortKey="Poles, Ma" uniqKey="Poles M">MA Poles</name></author><author><name sortKey="Tenner Racz, K" uniqKey="Tenner Racz K">K Tenner-Racz</name></author><author><name sortKey="Jean Pierre, P" uniqKey="Jean Pierre P">P Jean-Pierre</name></author><author><name sortKey="Manuelli, V" uniqKey="Manuelli V">V Manuelli</name></author><author><name sortKey="Lopez, P" uniqKey="Lopez P">P Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macal, M" uniqKey="Macal M">M Macal</name></author><author><name sortKey="Sankaran, S" uniqKey="Sankaran S">S Sankaran</name></author><author><name sortKey="Chun, Tw" uniqKey="Chun T">TW Chun</name></author><author><name sortKey="Reay, E" uniqKey="Reay E">E Reay</name></author><author><name sortKey="Flamm, J" uniqKey="Flamm J">J Flamm</name></author><author><name sortKey="Prindiville, Tj" uniqKey="Prindiville T">TJ Prindiville</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuetz, A" uniqKey="Schuetz A">A Schuetz</name></author><author><name sortKey="Deleage, C" uniqKey="Deleage C">C Deleage</name></author><author><name sortKey="Sereti, I" uniqKey="Sereti I">I Sereti</name></author><author><name sortKey="Rerknimitr, R" uniqKey="Rerknimitr R">R Rerknimitr</name></author><author><name sortKey="Phanuphak, N" uniqKey="Phanuphak N">N Phanuphak</name></author><author><name sortKey="Phuang Ngern, Y" uniqKey="Phuang Ngern Y">Y Phuang-Ngern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chun, Tw" uniqKey="Chun T">TW Chun</name></author><author><name sortKey="Nickle, Dc" uniqKey="Nickle D">DC Nickle</name></author><author><name sortKey="Justement, Js" uniqKey="Justement J">JS Justement</name></author><author><name sortKey="Meyers, Jh" uniqKey="Meyers J">JH Meyers</name></author><author><name sortKey="Roby, G" uniqKey="Roby G">G Roby</name></author><author><name sortKey="Hallahan, Cw" uniqKey="Hallahan C">CW Hallahan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yukl, Sa" uniqKey="Yukl S">SA Yukl</name></author><author><name sortKey="Shergill, Ak" uniqKey="Shergill A">AK Shergill</name></author><author><name sortKey="Mcquaid, K" uniqKey="Mcquaid K">K Mcquaid</name></author><author><name sortKey="Gianella, S" uniqKey="Gianella S">S Gianella</name></author><author><name sortKey="Lampiris, H" uniqKey="Lampiris H">H Lampiris</name></author><author><name sortKey="Hare, Cb" uniqKey="Hare C">CB Hare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gordon, Sn" uniqKey="Gordon S">SN Gordon</name></author><author><name sortKey="Cervasi, B" uniqKey="Cervasi B">B Cervasi</name></author><author><name sortKey="Odorizzi, P" uniqKey="Odorizzi P">P Odorizzi</name></author><author><name sortKey="Silverman, R" uniqKey="Silverman R">R Silverman</name></author><author><name sortKey="Aberra, F" uniqKey="Aberra F">F Aberra</name></author><author><name sortKey="Ginsberg, G" uniqKey="Ginsberg G">G Ginsberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kok, A" uniqKey="Kok A">A Kok</name></author><author><name sortKey="Hocqueloux, L" uniqKey="Hocqueloux L">L Hocqueloux</name></author><author><name sortKey="Hocini, H" uniqKey="Hocini H">H Hocini</name></author><author><name sortKey="Carriere, M" uniqKey="Carriere M">M Carriere</name></author><author><name sortKey="Lefrou, L" uniqKey="Lefrou L">L Lefrou</name></author><author><name sortKey="Guguin, A" uniqKey="Guguin A">A Guguin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anton, Pa" uniqKey="Anton P">PA Anton</name></author><author><name sortKey="Elliott, J" uniqKey="Elliott J">J Elliott</name></author><author><name sortKey="Poles, Ma" uniqKey="Poles M">MA Poles</name></author><author><name sortKey="Mcgowan, Im" uniqKey="Mcgowan I">IM Mcgowan</name></author><author><name sortKey="Matud, J" uniqKey="Matud J">J Matud</name></author><author><name sortKey="Hultin, Le" uniqKey="Hultin L">LE Hultin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poles, Ma" uniqKey="Poles M">MA Poles</name></author><author><name sortKey="Elliott, J" uniqKey="Elliott J">J Elliott</name></author><author><name sortKey="Taing, P" uniqKey="Taing P">P Taing</name></author><author><name sortKey="Anton, Pa" uniqKey="Anton P">PA Anton</name></author><author><name sortKey="Chen, Is" uniqKey="Chen I">IS Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mehandru, S" uniqKey="Mehandru S">S Mehandru</name></author><author><name sortKey="Poles, Ma" uniqKey="Poles M">MA Poles</name></author><author><name sortKey="Tenner Racz, K" uniqKey="Tenner Racz K">K Tenner-Racz</name></author><author><name sortKey="Manuelli, V" uniqKey="Manuelli V">V Manuelli</name></author><author><name sortKey="Jean Pierre, P" uniqKey="Jean Pierre P">P Jean-Pierre</name></author><author><name sortKey="Lopez, P" uniqKey="Lopez P">P Lopez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andersson, J" uniqKey="Andersson J">J Andersson</name></author><author><name sortKey="Boasso, A" uniqKey="Boasso A">A Boasso</name></author><author><name sortKey="Nilsson, J" uniqKey="Nilsson J">J Nilsson</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Shire, Nj" uniqKey="Shire N">NJ Shire</name></author><author><name sortKey="Lindback, S" uniqKey="Lindback S">S Lindback</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Epple, Hj" uniqKey="Epple H">HJ Epple</name></author><author><name sortKey="Loddenkemper, C" uniqKey="Loddenkemper C">C Loddenkemper</name></author><author><name sortKey="Kunkel, D" uniqKey="Kunkel D">D Kunkel</name></author><author><name sortKey="Troger, H" uniqKey="Troger H">H Troger</name></author><author><name sortKey="Maul, J" uniqKey="Maul J">J Maul</name></author><author><name sortKey="Moos, V" uniqKey="Moos V">V Moos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fagarasan, S" uniqKey="Fagarasan S">S Fagarasan</name></author><author><name sortKey="Kawamoto, S" uniqKey="Kawamoto S">S Kawamoto</name></author><author><name sortKey="Kanagawa, O" uniqKey="Kanagawa O">O Kanagawa</name></author><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mantis, Nj" uniqKey="Mantis N">NJ Mantis</name></author><author><name sortKey="Rol, N" uniqKey="Rol N">N Rol</name></author><author><name sortKey="Corthesy, B" uniqKey="Corthesy B">B Corthesy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levesque, Mc" uniqKey="Levesque M">MC Levesque</name></author><author><name sortKey="Moody, Ma" uniqKey="Moody M">MA Moody</name></author><author><name sortKey="Hwang, Kk" uniqKey="Hwang K">KK Hwang</name></author><author><name sortKey="Marshall, Dj" uniqKey="Marshall D">DJ Marshall</name></author><author><name sortKey="Whitesides, Jf" uniqKey="Whitesides J">JF Whitesides</name></author><author><name sortKey="Amos, Jd" uniqKey="Amos J">JD Amos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirota, K" uniqKey="Hirota K">K Hirota</name></author><author><name sortKey="Turner, Je" uniqKey="Turner J">JE Turner</name></author><author><name sortKey="Villa, M" uniqKey="Villa M">M Villa</name></author><author><name sortKey="Duarte, Jh" uniqKey="Duarte J">JH Duarte</name></author><author><name sortKey="Demengeot, J" uniqKey="Demengeot J">J Demengeot</name></author><author><name sortKey="Steinmetz, Om" uniqKey="Steinmetz O">OM Steinmetz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Jj" uniqKey="Hong J">JJ Hong</name></author><author><name sortKey="Amancha, Pk" uniqKey="Amancha P">PK Amancha</name></author><author><name sortKey="Rogers, K" uniqKey="Rogers K">K Rogers</name></author><author><name sortKey="Ansari, Aa" uniqKey="Ansari A">AA Ansari</name></author><author><name sortKey="Villinger, F" uniqKey="Villinger F">F Villinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrovas, C" uniqKey="Petrovas C">C Petrovas</name></author><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T Yamamoto</name></author><author><name sortKey="Gerner, My" uniqKey="Gerner M">MY Gerner</name></author><author><name sortKey="Boswell, Kl" uniqKey="Boswell K">KL Boswell</name></author><author><name sortKey="Wloka, K" uniqKey="Wloka K">K Wloka</name></author><author><name sortKey="Smith, Ec" uniqKey="Smith E">EC Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perreau, M" uniqKey="Perreau M">M Perreau</name></author><author><name sortKey="Savoye, Al" uniqKey="Savoye A">AL Savoye</name></author><author><name sortKey="De Crignis, E" uniqKey="De Crignis E">E De Crignis</name></author><author><name sortKey="Corpataux, Jm" uniqKey="Corpataux J">JM Corpataux</name></author><author><name sortKey="Cubas, R" uniqKey="Cubas R">R Cubas</name></author><author><name sortKey="Haddad, Ek" uniqKey="Haddad E">EK Haddad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Weatherall, C" uniqKey="Weatherall C">C Weatherall</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Alcantara, S" uniqKey="Alcantara S">S Alcantara</name></author><author><name sortKey="De Rose, R" uniqKey="De Rose R">R De Rose</name></author><author><name sortKey="Estaquier, J" uniqKey="Estaquier J">J Estaquier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colineau, L" uniqKey="Colineau L">L Colineau</name></author><author><name sortKey="Rouers, A" uniqKey="Rouers A">A Rouers</name></author><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T Yamamoto</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Urrutia, A" uniqKey="Urrutia A">A Urrutia</name></author><author><name sortKey="Pham, Hp" uniqKey="Pham H">HP Pham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kleinschek, Ma" uniqKey="Kleinschek M">MA Kleinschek</name></author><author><name sortKey="Boniface, K" uniqKey="Boniface K">K Boniface</name></author><author><name sortKey="Sadekova, S" uniqKey="Sadekova S">S Sadekova</name></author><author><name sortKey="Grein, J" uniqKey="Grein J">J Grein</name></author><author><name sortKey="Murphy, Ee" uniqKey="Murphy E">EE Murphy</name></author><author><name sortKey="Turner, Sp" uniqKey="Turner S">SP Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Trzpis, M" uniqKey="Trzpis M">M Trzpis</name></author><author><name sortKey="Mclaughlin, Pm" uniqKey="Mclaughlin P">PM Mclaughlin</name></author><author><name sortKey="De Leij, Lm" uniqKey="De Leij L">LM De Leij</name></author><author><name sortKey="Harmsen, Mc" uniqKey="Harmsen M">MC Harmsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Somsouk, M" uniqKey="Somsouk M">M Somsouk</name></author><author><name sortKey="Estes, Jd" uniqKey="Estes J">JD Estes</name></author><author><name sortKey="Deleage, C" uniqKey="Deleage C">C Deleage</name></author><author><name sortKey="Dunham, Rm" uniqKey="Dunham R">RM Dunham</name></author><author><name sortKey="Albright, R" uniqKey="Albright R">R Albright</name></author><author><name sortKey="Inadomi, Jm" uniqKey="Inadomi J">JM Inadomi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koelsch, Kk" uniqKey="Koelsch K">KK Koelsch</name></author><author><name sortKey="Boesecke, C" uniqKey="Boesecke C">C Boesecke</name></author><author><name sortKey="Mcbride, K" uniqKey="Mcbride K">K Mcbride</name></author><author><name sortKey="Gelgor, L" uniqKey="Gelgor L">L Gelgor</name></author><author><name sortKey="Fahey, P" uniqKey="Fahey P">P Fahey</name></author><author><name sortKey="Natarajan, V" uniqKey="Natarajan V">V Natarajan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smit Mcbride, Z" uniqKey="Smit Mcbride Z">Z Smit-McBride</name></author><author><name sortKey="Mattapallil, Jj" uniqKey="Mattapallil J">JJ Mattapallil</name></author><author><name sortKey="Mcchesney, M" uniqKey="Mcchesney M">M Mcchesney</name></author><author><name sortKey="Ferrick, D" uniqKey="Ferrick D">D Ferrick</name></author><author><name sortKey="Dandekar, S" uniqKey="Dandekar S">S Dandekar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Veazey, Rs" uniqKey="Veazey R">RS Veazey</name></author><author><name sortKey="Rosenzweig, M" uniqKey="Rosenzweig M">M Rosenzweig</name></author><author><name sortKey="Shvetz, De" uniqKey="Shvetz D">DE Shvetz</name></author><author><name sortKey="Pauley, Dr" uniqKey="Pauley D">DR Pauley</name></author><author><name sortKey="Demaria, M" uniqKey="Demaria M">M Demaria</name></author><author><name sortKey="Chalifoux, Lv" uniqKey="Chalifoux L">LV Chalifoux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Damme, N" uniqKey="Van Damme N">N Van Damme</name></author><author><name sortKey="Baeten, D" uniqKey="Baeten D">D Baeten</name></author><author><name sortKey="De Vos, M" uniqKey="De Vos M">M De Vos</name></author><author><name sortKey="Demetter, P" uniqKey="Demetter P">P Demetter</name></author><author><name sortKey="Elewaut, D" uniqKey="Elewaut D">D Elewaut</name></author><author><name sortKey="Mielants, H" uniqKey="Mielants H">H Mielants</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaunders, Jj" uniqKey="Zaunders J">JJ Zaunders</name></author><author><name sortKey="Dyer, Wb" uniqKey="Dyer W">WB Dyer</name></author><author><name sortKey="Munier, Ml" uniqKey="Munier M">ML Munier</name></author><author><name sortKey="Ip, S" uniqKey="Ip S">S Ip</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Amyes, E" uniqKey="Amyes E">E Amyes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reynes, J" uniqKey="Reynes J">J Reynes</name></author><author><name sortKey="Portales, P" uniqKey="Portales P">P Portales</name></author><author><name sortKey="Segondy, M" uniqKey="Segondy M">M Segondy</name></author><author><name sortKey="Baillat, V" uniqKey="Baillat V">V Baillat</name></author><author><name sortKey="Andre, P" uniqKey="Andre P">P Andre</name></author><author><name sortKey="Reant, B" uniqKey="Reant B">B Reant</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaunders, J" uniqKey="Zaunders J">J Zaunders</name></author><author><name sortKey="Jing, J" uniqKey="Jing J">J Jing</name></author><author><name sortKey="Leipold, M" uniqKey="Leipold M">M Leipold</name></author><author><name sortKey="Maecker, H" uniqKey="Maecker H">H Maecker</name></author><author><name sortKey="Kelleher, Ad" uniqKey="Kelleher A">AD Kelleher</name></author><author><name sortKey="Koch, I" uniqKey="Koch I">I Koch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaunders, Jj" uniqKey="Zaunders J">JJ Zaunders</name></author><author><name sortKey="Ip, S" uniqKey="Ip S">S Ip</name></author><author><name sortKey="Munier, Ml" uniqKey="Munier M">ML Munier</name></author><author><name sortKey="Kaufmann, De" uniqKey="Kaufmann D">DE Kaufmann</name></author><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author><author><name sortKey="Brereton, C" uniqKey="Brereton C">C Brereton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hey Cunningham, Wj" uniqKey="Hey Cunningham W">WJ Hey-Cunningham</name></author><author><name sortKey="Murray, Jm" uniqKey="Murray J">JM Murray</name></author><author><name sortKey="Natarajan, V" uniqKey="Natarajan V">V Natarajan</name></author><author><name sortKey="Amin, J" uniqKey="Amin J">J Amin</name></author><author><name sortKey="Moore, Cl" uniqKey="Moore C">CL Moore</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sasson, S" uniqKey="Sasson S">S Sasson</name></author><author><name sortKey="Zaunders, J" uniqKey="Zaunders J">J Zaunders</name></author><author><name sortKey="Zanetti, G" uniqKey="Zanetti G">G Zanetti</name></author><author><name sortKey="King, E" uniqKey="King E">E King</name></author><author><name sortKey="Merlin, K" uniqKey="Merlin K">K Merlin</name></author><author><name sortKey="Smith, D" uniqKey="Smith D">D Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunham, Rm" uniqKey="Dunham R">RM Dunham</name></author><author><name sortKey="Cervasi, B" uniqKey="Cervasi B">B Cervasi</name></author><author><name sortKey="Brenchley, Jm" uniqKey="Brenchley J">JM Brenchley</name></author><author><name sortKey="Albrecht, H" uniqKey="Albrecht H">H Albrecht</name></author><author><name sortKey="Weintrob, A" uniqKey="Weintrob A">A Weintrob</name></author><author><name sortKey="Sumpter, B" uniqKey="Sumpter B">B Sumpter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Napolitano, L" uniqKey="Napolitano L">L Napolitano</name></author><author><name sortKey="Grant, R" uniqKey="Grant R">R Grant</name></author><author><name sortKey="Deeks, S" uniqKey="Deeks S">S Deeks</name></author><author><name sortKey="Schmidt, D" uniqKey="Schmidt D">D Schmidt</name></author><author><name sortKey="De Rosa, S" uniqKey="De Rosa S">S De Rosa</name></author><author><name sortKey="Herzenberg, L" uniqKey="Herzenberg L">L Herzenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mackay, Lk" uniqKey="Mackay L">LK Mackay</name></author><author><name sortKey="Stock, At" uniqKey="Stock A">AT Stock</name></author><author><name sortKey="Ma, Jz" uniqKey="Ma J">JZ Ma</name></author><author><name sortKey="Jones, Cm" uniqKey="Jones C">CM Jones</name></author><author><name sortKey="Kent, Sj" uniqKey="Kent S">SJ Kent</name></author><author><name sortKey="Mueller, Sn" uniqKey="Mueller S">SN Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seddiki, N" uniqKey="Seddiki N">N Seddiki</name></author><author><name sortKey="Santner Nanan, B" uniqKey="Santner Nanan B">B Santner-Nanan</name></author><author><name sortKey="Martinson, J" uniqKey="Martinson J">J Martinson</name></author><author><name sortKey="Zaunders, J" uniqKey="Zaunders J">J Zaunders</name></author><author><name sortKey="Sasson, S" uniqKey="Sasson S">S Sasson</name></author><author><name sortKey="Landay, A" uniqKey="Landay A">A Landay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costiniuk, Ct" uniqKey="Costiniuk C">CT Costiniuk</name></author><author><name sortKey="Angel, Jb" uniqKey="Angel J">JB Angel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yukl, Sa" uniqKey="Yukl S">SA Yukl</name></author><author><name sortKey="Shergill, Ak" uniqKey="Shergill A">AK Shergill</name></author><author><name sortKey="Girling, V" uniqKey="Girling V">V Girling</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Killian, M" uniqKey="Killian M">M Killian</name></author><author><name sortKey="Epling, L" uniqKey="Epling L">L Epling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klatt, Nr" uniqKey="Klatt N">NR Klatt</name></author><author><name sortKey="Vinton, Cl" uniqKey="Vinton C">CL Vinton</name></author><author><name sortKey="Lynch, Rm" uniqKey="Lynch R">RM Lynch</name></author><author><name sortKey="Canary, La" uniqKey="Canary L">LA Canary</name></author><author><name sortKey="Ho, J" uniqKey="Ho J">J Ho</name></author><author><name sortKey="Darrah, Pa" uniqKey="Darrah P">PA Darrah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nilssen, De" uniqKey="Nilssen D">DE Nilssen</name></author><author><name sortKey="Oktedalen, O" uniqKey="Oktedalen O">O Oktedalen</name></author><author><name sortKey="Brandtzaeg, P" uniqKey="Brandtzaeg P">P Brandtzaeg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaunders, J" uniqKey="Zaunders J">J Zaunders</name></author><author><name sortKey="Mak, G" uniqKey="Mak G">G Mak</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Seddiki, N" uniqKey="Seddiki N">N Seddiki</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Cooper, D" uniqKey="Cooper D">D Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaunders, Jj" uniqKey="Zaunders J">JJ Zaunders</name></author><author><name sortKey="Kaufmann, Gr" uniqKey="Kaufmann G">GR Kaufmann</name></author><author><name sortKey="Cunningham, Ph" uniqKey="Cunningham P">PH Cunningham</name></author><author><name sortKey="Smith, D" uniqKey="Smith D">D Smith</name></author><author><name sortKey="Grey, P" uniqKey="Grey P">P Grey</name></author><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaunders, Jj" uniqKey="Zaunders J">JJ Zaunders</name></author><author><name sortKey="Munier, Ml" uniqKey="Munier M">ML Munier</name></author><author><name sortKey="Kaufmann, De" uniqKey="Kaufmann D">DE Kaufmann</name></author><author><name sortKey="Ip, S" uniqKey="Ip S">S Ip</name></author><author><name sortKey="Grey, P" uniqKey="Grey P">P Grey</name></author><author><name sortKey="Smith, D" uniqKey="Smith D">D Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, T" uniqKey="Feng T">T Feng</name></author><author><name sortKey="Elson, Co" uniqKey="Elson C">CO Elson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Pd" uniqKey="Smith P">PD Smith</name></author><author><name sortKey="Smythies, Le" uniqKey="Smythies L">LE Smythies</name></author><author><name sortKey="Shen, R" uniqKey="Shen R">R Shen</name></author><author><name sortKey="Greenwell Wild, T" uniqKey="Greenwell Wild T">T Greenwell-Wild</name></author><author><name sortKey="Gliozzi, M" uniqKey="Gliozzi M">M Gliozzi</name></author><author><name sortKey="Wahl, Sm" uniqKey="Wahl S">SM Wahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Savkovic, B" uniqKey="Savkovic B">B Savkovic</name></author><author><name sortKey="Macpherson, Jl" uniqKey="Macpherson J">JL Macpherson</name></author><author><name sortKey="Zaunders, J" uniqKey="Zaunders J">J Zaunders</name></author><author><name sortKey="Kelleher, Ad" uniqKey="Kelleher A">AD Kelleher</name></author><author><name sortKey="Knop, Ae" uniqKey="Knop A">AE Knop</name></author><author><name sortKey="Pond, S" uniqKey="Pond S">S Pond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klonowski, Kd" uniqKey="Klonowski K">KD Klonowski</name></author><author><name sortKey="Williams, Kj" uniqKey="Williams K">KJ Williams</name></author><author><name sortKey="Marzo, Al" uniqKey="Marzo A">AL Marzo</name></author><author><name sortKey="Blair, Da" uniqKey="Blair D">DA Blair</name></author><author><name sortKey="Lingenheld, Eg" uniqKey="Lingenheld E">EG Lingenheld</name></author><author><name sortKey="Lefrancois, L" uniqKey="Lefrancois L">L Lefrancois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Kg" uniqKey="Anderson K">KG Anderson</name></author><author><name sortKey="Sung, H" uniqKey="Sung H">H Sung</name></author><author><name sortKey="Skon, Cn" uniqKey="Skon C">CN Skon</name></author><author><name sortKey="Lefrancois, L" uniqKey="Lefrancois L">L Lefrancois</name></author><author><name sortKey="Deisinger, A" uniqKey="Deisinger A">A Deisinger</name></author><author><name sortKey="Vezys, V" uniqKey="Vezys V">V Vezys</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcbride, K" uniqKey="Mcbride K">K McBride</name></author><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name></author><author><name sortKey="Bailey, M" uniqKey="Bailey M">M Bailey</name></author><author><name sortKey="Seddiki, N" uniqKey="Seddiki N">N Seddiki</name></author><author><name sortKey="Suzuki, K" uniqKey="Suzuki K">K Suzuki</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name></noRegion><name sortKey="Bailey, Michelle" sort="Bailey, Michelle" uniqKey="Bailey M" first="Michelle" last="Bailey">Michelle Bailey</name><name sortKey="Boyd, Mark A" sort="Boyd, Mark A" uniqKey="Boyd M" first="Mark A." last="Boyd">Mark A. Boyd</name><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name><name sortKey="Cooper, David A" sort="Cooper, David A" uniqKey="Cooper D" first="David A." last="Cooper">David A. Cooper</name><name sortKey="Danta, Mark" sort="Danta, Mark" uniqKey="Danta M" first="Mark" last="Danta">Mark Danta</name><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name><name sortKey="Kelleher, Anthony D" sort="Kelleher, Anthony D" uniqKey="Kelleher A" first="Anthony D." last="Kelleher">Anthony D. Kelleher</name><name sortKey="Koelsch, Kersten K" sort="Koelsch, Kersten K" uniqKey="Koelsch K" first="Kersten K." last="Koelsch">Kersten K. Koelsch</name><name sortKey="Mak, Gerald" sort="Mak, Gerald" uniqKey="Mak G" first="Gerald" last="Mak">Gerald Mak</name><name sortKey="Marks, Katherine" sort="Marks, Katherine" uniqKey="Marks K" first="Katherine" last="Marks">Katherine Marks</name><name sortKey="Templeton, David J" sort="Templeton, David J" uniqKey="Templeton D" first="David J." last="Templeton">David J. Templeton</name><name sortKey="Templeton, David J" sort="Templeton, David J" uniqKey="Templeton D" first="David J." last="Templeton">David J. Templeton</name><name sortKey="Xu, Yin" sort="Xu, Yin" uniqKey="Xu Y" first="Yin" last="Xu">Yin Xu</name><name sortKey="Zaunders, John" sort="Zaunders, John" uniqKey="Zaunders J" first="John" last="Zaunders">John Zaunders</name></country><country name="France"><noRegion><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name></noRegion><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name><name sortKey="Seddiki, Nabila" sort="Seddiki, Nabila" uniqKey="Seddiki N" first="Nabila" last="Seddiki">Nabila Seddiki</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002278 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002278 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5075890
|texte= CD4+ T Follicular Helper and IgA+ B Cell Numbers in Gut Biopsies from HIV-Infected Subjects on Antiretroviral Therapy Are Similar to HIV-Uninfected Individuals
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27822211" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |